tert-Butyl carbamate → HCID 67774056, compound

HRID 1802301Notes

Reaction equation

HRID 1802301 reaction equation
Br[C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[N:12]=3)[N:10]=[C:4]2[CH:3]=1.[C:18](=[O:25])([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[NH2:19]>>[C:21]([O:20][C:18](=[O:25])[NH:19][C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[N:12]=3)[N:10]=[C:4]2[CH:3]=1)([CH3:24])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 677743317-Bromo-2-(6-fluoropyridin-2-YL)-[1,2,4]triazolo[1,5-A]pyridine

Product 1

HCID 67774056HCID 67774056, compoundYield 32.5%

Procedure

The product was prepared in the same manner as described in example 1c using 7-bromo-2-(6-fluoropyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyridine (1.44 g, 4.91 mmol) and tert-butyl carbamate (691 mg, 5.9 mmol) as starting materials. The reaction affords [2-(6-fluoro-pyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-carbamic acid tert-butyl ester (526 mg, 32.5%), as off-white crystals. MS: m/z=330.0 (M+H+).

Workup

  1. customThe product was prepared in the same manner

Sources & evidence

ORD record
ord-667468a434a24f5ea761bfc4b1e02594
Source dataset
uspto-grants-2013_01
Patent number
US08349824B2

Reaction notes

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