tert-Butyl carbamate → HCID 67777207, compound

HRID 1802306Notes

Reaction equation

HRID 1802306 reaction equation
Br[C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[C:9]([N:11]([CH:13]3[CH2:15][CH2:14]3)[CH3:12])[N:10]=[C:4]2[CH:3]=1.[C:16](=[O:23])([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[NH2:17]>>[C:19]([O:18][C:16](=[O:23])[NH:17][C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[C:9]([N:11]([CH:13]3[CH2:15][CH2:14]3)[CH3:12])[N:10]=[C:4]2[CH:3]=1)([CH3:22])([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 67774606HCID 67774606, compound

Product 1

HCID 67777207HCID 67777207, compoundYield 55.2%

Procedure

The product was prepared in the same manner as described in example 8e using 7-bromo-N-cyclopropyl-N-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine (540 mg, 2.02 mmol) and tert-butyl carbamate (284 mg, 2.43 mmol) as starting materials. The reaction affords [2-(cyclopropyl-methyl-amino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-carbamic acid tert-butyl ester (338 mg, 55.03%) as light yellow crystals. mp: 323.1° C., MS: m/z=397.1 (M+H+).

Workup

  1. customThe product was prepared in the same manner

Sources & evidence

ORD record
ord-a8f14bcaa38045708fded4d60175c81a
Source dataset
uspto-grants-2013_01
Patent number
US08349824B2

Reaction notes

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