Azetidine → Azetidin-1-yl-(1-methyl-1H-pyrazol-4-yl)-methanone

HRID 1802310Notes

Reaction equation

HRID 1802310 reaction equation
[CH3:1][N:2]([CH3:11])[C:3]([C:5]1[CH:6]=[N:7][N:8]([CH3:10])[CH:9]=1)=[O:4].[CH3:12]N1C=C(C(O)=O)C=N1.N1CCC1>>[N:2]1([C:3]([C:5]2[CH:6]=[N:7][N:8]([CH3:10])[CH:9]=2)=[O:4])[CH2:11][CH2:12][CH2:1]1

Participants

4

Reactant 3

HCID 10422AzetidineHCID 6431601-Methyl-1H-pyrazole-4-carboxylic acidHCID 59551573N,N,1-trimethyl-1H-pyrazole-4-carboxamide

Product 1

HCID 58446814Azetidin-1-yl-(1-methyl-1H-pyrazol-4-yl)-methanone

Procedure

This compound was prepared in analogy to 1-methyl-1H-pyrazole-4-carboxylic acid dimethylamide (Example 97, step a) from 1-methyl-1H-pyrazole-4-carboxylic acid (1.0 g, 7.93 mmol) and azetidine (475 mg, 8.33 mmol). Yield: 1.31 g (92%); light yellow solid; MS: m/z=166.1 ([M+H]+).

Sources & evidence

ORD record
ord-92b86a5cba0441d1b0d282c96d59c8e2
Source dataset
uspto-grants-2013_01
Patent number
US08349824B2

Reaction notes

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