6-Iodo-2,3-dimethoxypyridine → 5,6-Dimethoxypicolinonitrile

HRID 1802346Notes

Reaction equation

HRID 1802346 reaction equation
[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[CH:7][CH:6]=[C:5](I)[N:4]=1.[Cu](C#N)[C:13]#[N:14]>CN(C=O)C>[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[CH:7][CH:6]=[C:5]([C:13]#[N:14])[N:4]=1

Participants

4

Reactant 2

HCID 453617466-Iodo-2,3-dimethoxypyridineHCID 178418260HCID 178418260, compound

Product 1

HCID 467367605,6-Dimethoxypicolinonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
150 °C

Procedure

To a solution of 2,3-dimethoxy-6-iodopyridine (5-4, 24.0 g, 91 mmol) in DMF (181 mL) was added copper cyanide (9.73 g, 109 mmol) and heated to 150° C. for 20 minutes in a microwave reactor. The mixture was partitioned between water and EtOAc. The organic phase was washed with brine, dried over Na2SO4, filtered and concentrated. The crude material was purified by gradient elution on silica gel (0 to 40% EtOAc in hexanes) to yield the desired product (5-5) as an off-white crystalline powder. ESI+MS [M+H]+ C8H8N2O2: 165.0 found, 165.1 required.

Workup

  1. customThe mixture was partitioned between water and EtOAc
  2. washThe organic phase was washed with brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe crude material was purified by gradient elution on silica gel (0 to 40% EtOAc in hexanes)

Sources & evidence

ORD record
ord-d5d7a4ec1a8e416e81cfee121bd36633
Source dataset
uspto-grants-2013_01
Patent number
US08349872B2

Reaction notes

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