反应详情

To a solution of 1.63 g (12.5 mmol) of 2-(tetrahydro-pyran-4-yl)-ethanol in pyridine (15 mL) are added 3.58 g (18.8 mmol) of p-toluenesulfonylchloride. The reaction is stirred at room temperature for 5 h. The reaction mixture is concentrated under reduced pressure. The residue is dissolved 2M aqueous HCl solution (20 mL) and extracted with ethyl acetate (3×50 mL). The combined organic extracts are dried over Na2SO4, filtered and the solvent is removed to give 1.9 g of toluene-4-sulfonic acid 2-(tetrahydro-pyran-4-yl)-ethyl ester as off-white crystalline solid. Yield: 53%; ES-MS: m/z 285 [M+H]

1. concentrationThe reaction mixture is concentrated under reduced pressure
2. dissolutionThe residue is dissolved 2M aqueous HCl solution (20 mL)
3. extractionextracted with ethyl acetate (3×50 mL)
4. dry with materialThe combined organic extracts are dried over Na2SO4
5. filtrationfiltered
6. customthe solvent is removed