反应详情

温度

47.5 °C

2-amino-4-methoxy-5-(3-chloropropoxy)benzoic acid (450 gm), formamide (2250 ml) and ammonium formate (200 gm) were heated to 170-180° C. for 3-4 hours. The reaction mass was concentrated under reduced pressure at 140-150° C. The residue was stirred in methanol (1000 ml) at 45-50° C. and cooled to 5-10° C. The solid obtained was filtered to yield the title compound (420 gm, 90% yield).

1. concentrationThe reaction mass was concentrated under reduced pressure at 140-150° C
2. temperaturecooled to 5-10° C
3. customThe solid obtained
4. filtrationwas filtered