N-cyclopropylsulfamoyl chloride → HCID 68921530、化合物

HRID 1803081ノート

反応式

HRID 1803081 の反応式
[CH3:1][O:2][C:3]1[CH:21]=[CH:20][CH:19]=[CH:18][C:4]=1[CH2:5][NH:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([NH2:17])[CH:13]=2)[N:8]=1.[CH:22]1([NH:25][S:26](Cl)(=[O:28])=[O:27])[CH2:24][CH2:23]1>N1C=CC=CC=1>[CH:22]1([NH:25][S:26]([NH:17][C:12]2[CH:13]=[C:14]3[C:9](=[CH:10][CH:11]=2)[N:8]=[C:7]([NH:6][CH2:5][C:4]2[CH:18]=[CH:19][CH:20]=[CH:21][C:3]=2[O:2][CH3:1])[CH:16]=[CH:15]3)(=[O:28])=[O:27])[CH2:24][CH2:23]1

参加物

4

反応物 2

HCID 22279368N-cyclopropylsulfamoyl chlorideHCID 43450845N2-(2-Methoxy-benzyl)-quinoline-2,6-diamine

生成物 1

HCID 68921530HCID 68921530、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

N2-(2-Methoxy-benzyl)-quinoline-2,6-diamine (example 10, step B, 40 mg, 0.143 mmol) was dissolved in 1 mL pyridine. Cyclopropylsulfamoyl chloride (29 mg, 0.186 mmol) was added and the reaction mixture was stirred at room temperature overnight. The solvent was evaporated off and the residue purified by flash chromatography on silica gel (heptane/ethyl acetate 90:10→34:66 gradient). The title compound was obtained as a yellow solid (22 mg, 39%), MS: m/e=397.5 (M+H+).

後処理

  1. customThe solvent was evaporated off
  2. customthe residue purified by flash chromatography on silica gel (heptane/ethyl acetate 90:10→34:66 gradient)

出典と根拠

ORDレコード
ord-9e1d275f73bd451cac7ee3b7db328294
出典データセット
uspto-grants-2013_01
特許番号
US08350028B2

反応ノート

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