Ammonia → HCID 86649906, compound

HRID 1803140Notes

Reaction equation

HRID 1803140 reaction equation
[NH3:1].[Cl:2][C:3]1[N:4]=[CH:5][N:6]([C:8]2[C:13]([F:14])=[CH:12][C:11]([N:15]=[C:16]=[S:17])=[CH:10][C:9]=2[F:18])[CH:7]=1>>[Cl:2][C:3]1[N:4]=[CH:5][N:6]([C:8]2[C:9]([F:18])=[CH:10][C:11]([NH:15][C:16]([NH2:1])=[S:17])=[CH:12][C:13]=2[F:14])[CH:7]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 86649904HCID 86649904, compound

Product 1

HCID 86649906HCID 86649906, compoundYield 100%

Procedure

Step J (4): Methanolic ammonia (2.0 M, 5 mL, 10 mmol) was added to a flask charged with 4-chloro-1-(2,6-difluoro-4-isothiocyanatophenyl)-1H-imidazole (195 mg, 0.718 mmol). After 3 h, the reaction mixture was concentrated to dryness in vacuo to afford 1-(4-(4-chloro-1H-imidazol-1-yl)-3,5-difluorophenyl)thiourea (207 mg, 100% yield) as a white solid. LC-MS (M+H)+ 289.2

Workup

  1. concentrationthe reaction mixture was concentrated to dryness in vacuo

Sources & evidence

ORD record
ord-821b69401b4f47ca97a380c00779fa4d
Source dataset
uspto-grants-2013_01
Patent number
US08349880B2

Reaction notes

Loading…