Ammonia → HCID 86649906, compound

Participants

Reaction Steps

Step J (4): Methanolic ammonia (2.0 M, 5 mL, 10 mmol) was added to a flask charged with 4-chloro-1-(2,6-difluoro-4-isothiocyanatophenyl)-1H-imidazole (195 mg, 0.718 mmol). After 3 h, the reaction mixture was concentrated to dryness in vacuo to afford 1-(4-(4-chloro-1H-imidazol-1-yl)-3,5-difluorophenyl)thiourea (207 mg, 100% yield) as a white solid. LC-MS (M+H)+ 289.2

Provenance & Evidence