Ammonia → HCID 86649911, compound

HRID 1803155Notes

Reaction equation

HRID 1803155 reaction equation
[NH3:1].[Cl:2][C:3]1[N:4]=[CH:5][N:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][C:11]([N:16]=[C:17]=[S:18])=[CH:10][C:9]=2[F:19])[CH:7]=1>>[Cl:2][C:3]1[N:4]=[CH:5][N:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][C:11]([NH:16][C:17]([NH2:1])=[S:18])=[CH:10][C:9]=2[F:19])[CH:7]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 86649912HCID 86649912, compound

Product 1

HCID 86649911HCID 86649911, compoundYield 100%

Procedure

Step M (8): Methanolic ammonia (2.0 M, 5 mL, 10 mmol) was added to a flask charged with 4-chloro-1-(2-fluoro-4-isothiocyanato-6-methoxyphenyl)-1H-imidazole (230 mg, 0.811 mmol). After 2 h, the reaction mixture was concentrated in vacuo to afford 1-(4-(4-chloro-1H-imidazol-1-yl)-3-fluoro-5-methoxyphenyl)thiourea (244 mg, 100% yield). LC-MS (M+H)+ 301.1.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-7a7e8bfcb84243a9a79a324166dbf66a
Source dataset
uspto-grants-2013_01
Patent number
US08349880B2

Reaction notes

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