Ammonia → HCID 86649911, compound

Participants

Reaction Steps

Step M (8): Methanolic ammonia (2.0 M, 5 mL, 10 mmol) was added to a flask charged with 4-chloro-1-(2-fluoro-4-isothiocyanato-6-methoxyphenyl)-1H-imidazole (230 mg, 0.811 mmol). After 2 h, the reaction mixture was concentrated in vacuo to afford 1-(4-(4-chloro-1H-imidazol-1-yl)-3-fluoro-5-methoxyphenyl)thiourea (244 mg, 100% yield). LC-MS (M+H)+ 301.1.

Provenance & Evidence