Ammonia → HCID 86649915, compound

HRID 1803160Notes

Reaction equation

HRID 1803160 reaction equation
[NH3:1].[F:2][CH:3]([F:20])[C:4]1[N:5]=[CH:6][N:7]([C:9]2[CH:14]=[CH:13][C:12]([N:15]=[C:16]=[S:17])=[CH:11][C:10]=2[O:18][CH3:19])[CH:8]=1>>[F:20][CH:3]([F:2])[C:4]1[N:5]=[CH:6][N:7]([C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16]([NH2:1])=[S:17])=[CH:11][C:10]=2[O:18][CH3:19])[CH:8]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 86649914HCID 86649914, compound

Product 1

HCID 86649915HCID 86649915, compoundYield 87%

Procedure

Step N (6): Methanolic ammonia (2.0 M, 100 mL, 200 mmol) was added to a flask charged with 4-(difluoromethyl)-1-(4-isothiocyanato-2-methoxyphenyl)-1H-imidazole (2.26 g, 8.1 mmol). After 16 h, the reaction mixture was concentrated in vacuo to afford 1-(4-(4-(difluoromethyl)-1H-imidazol-1-yl)-3-methoxyphenyl)thiourea (2.08 g, 87% yield). LC-MS (M+H)+ 299.1.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-d776b12238c04b99b357b5352be1f282
Source dataset
uspto-grants-2013_01
Patent number
US08349880B2

Reaction notes

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