Ammonia → HCID 86649915, compound

Participants

Reaction Steps

Step N (6): Methanolic ammonia (2.0 M, 100 mL, 200 mmol) was added to a flask charged with 4-(difluoromethyl)-1-(4-isothiocyanato-2-methoxyphenyl)-1H-imidazole (2.26 g, 8.1 mmol). After 16 h, the reaction mixture was concentrated in vacuo to afford 1-(4-(4-(difluoromethyl)-1H-imidazol-1-yl)-3-methoxyphenyl)thiourea (2.08 g, 87% yield). LC-MS (M+H)+ 299.1.

Provenance & Evidence