HRID1803363

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID787

Hydroxylamine

H3NO

结构：O=[N+]([O-])c1c(OCc2ccccc2)nc2ccccc2c1Cl

HCID21075762

未命名化合物

结构：O=[N+]([O-])c1c(OCc2ccccc2)nc2cccnc2c1Cl

HCID66650176

未命名化合物

PRODUCTS

生成物

结构：Nc1c([N+](=O)[O-])c(OCc2ccccc2)nc2cccnc12

HCID66649873

未命名化合物

结构：Nc1c([N+](=O)[O-])c(OCc2ccccc2)nc2ccccc12

HCID66649911

未命名化合物

PROCEDURE

实验过程

In step (5) of Reaction Scheme V, a benzyloxy-4-chloro-3-nitroquinoline or benzyloxy-4-chloro-3-nitro[1,5]naphthyridine of Formula LV is treated with an amino alcohol of Formula XVI to provide a benzyloxy-3-nitroquinolin-4-amine or benzyloxy-3-nitro[1,5]naphthyridin-4-amine of Formula LVI. The reaction is conveniently carried out according to the methods described in step (1) of Reaction Scheme I.

WORKUP

后处理

customIn step (5) of Reaction Scheme V

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-be747bbda6d64550a9c73c848def33b6
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08350034B2
来源说明: uspto-grants-2013_01

反应 SMILES

[CH2:1]([O:8][C:9]1[C:18]([N+:19]([O-:21])=[O:20])=[C:17](Cl)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:23]([O:30][C:31]1[C:40]([N+:41]([O-:43])=[O:42])=[C:39](Cl)[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][N:37]=2)[N:32]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.NO>>[CH2:1]([O:8][C:9]1[C:18]([N+:19]([O-:21])=[O:20])=[C:17]([NH2:32])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:23]([O:30][C:31]1[C:40]([N+:41]([O-:43])=[O:42])=[C:39]([NH2:10])[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][N:37]=2)[N:32]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1