Dichloromethane → HCID 59580658, compound

HRID 1803429Notes

Reaction equation

HRID 1803429 reaction equation
[CH3:1][N:2]([C:9]1[S:13][C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[N:11][C:10]=1[CH3:20])[C:3](=[O:8])[CH2:4][CH2:5][S:6][CH3:7].B1([O-])OO1.[OH2:25].[OH2:26].O.O.[Na+].C([O-])(O)=O.[Na+].ClCCl>C(O)(=O)C>[CH3:7][S:6]([CH2:5][CH2:4][C:3]([N:2]([CH3:1])[C:9]1[S:13][C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[N:11][C:10]=1[CH3:20])=[O:8])(=[O:26])=[O:25]

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 516892Sodium BicarbonateHCID 23693097Sodium;3-oxidodioxaborirane;tetrahydrateHCID 59580724HCID 59580724, compound2×

Product 1

HCID 59580658HCID 59580658, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
65 °C

Procedure

To N-methyl-N-(4-methyl-2-pyridin-3-yl-thiazol-5-yl)-3-methylsulfanyl-propionamide (Compound 19, 132 mg, 0.43 mmol) in glacial acetic acid (4.0 mL) was added sodium perborate tetrahydrate (165 mg, 1.07 mmol), and the mixture was heated at 65° C. for 16 h. The reaction mixture was carefully poured into a separatory funnel containing saturated aqueous NaHCO3 resulting in gas evolution. When the gas evolution had ceased, dichloromethane was added and the layers were separated. The aqueous layer was extracted twice with dichloromethane, and all the organic layers were combined, dried over MgSO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (0 to 10% methanol/dichloromethane) to give the desired product as a white oil (77 mg, 65%): IR (KBr) 2927, 1675 cm−1; 1H NMR (300 MHz, CDCl3) δ 9.10 (d, J=2.0 Hz, 1H), 8.68 (dd, J=4.9, 1.7 Hz, 1H), 8.19 (dt, J=8.2, 2.0 Hz, 1H), 7.41 (dd, J=7.9, 4.9 Hz, 1H), 3.41 (t, J=6.9 Hz, 2H), 3.28 (s, 3H), 2.96 (s, 3H), 2.77 (t, J=7.3 Hz, 2H), 2.38 (s, 3H); ESIMS m/z 340.2 (M+1).

Workup

  1. additionThe reaction mixture was carefully poured into a separatory funnel
  2. customthe layers were separated
  3. extractionThe aqueous layer was extracted twice with dichloromethane
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure
  7. customThe crude product was purified by silica gel column chromatography (0 to 10% methanol/dichloromethane)

Sources & evidence

ORD record
ord-91a6d891391a4c46aa5c12ae7bb1f858
Source dataset
uspto-grants-2013_01
Patent number
US08350044B2

Reaction notes

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