反应详情

A mixture of 1,4-dichloro-6-nitro-phthalazine (1.24 g, 5.09 mmol), EtOH (20 mL), saturated aqueous NH4Cl (20 mL) and iron powder (1.42 g, 25.47 mmol) was heated to reflux for 4 h then concentrated. The residue was taken up in EtOAc washed with saturated aqueous NaHCO3, brine, dried (Na2SO4) and concentrated. Column chromatography (Hexanes/EtOAc) afforded the desired product (0.33 g, 30%) as a pale yellow solid.

1. temperaturewas heated
2. temperatureto reflux for 4 h
3. concentrationthen concentrated
4. washwashed with saturated aqueous NaHCO3, brine
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated