HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1803632Generated: October 27, 2026
Phosphoric Acid → 4-Hydroxy-5-(3-methoxybenzyl)cyclopent-2-enone
https://huagongshe.com/reaction/1803632
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Monobasic potassium phosphate | HCID 516951 | — |
| Reactant | 1-(Furan-2-yl)-2-(3-methoxyphenyl)ethan-1-ol | HCID 62717468 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Hydroxy-5-(3-methoxybenzyl)cyclopent-2-enone | HCID 71170031 | — |
| Product | 4-Hydroxy-2-(3-methoxybenzyl)cyclopent-2-enone | HCID 71170038 | — |
Reaction Steps
1-(Furan-2-yl)-2-(3-methoxyphenyl)ethan-1-ol (20 g, 91.7 mmol) and KH2PO4 (0.4 g, 0.02 mmol) was added to H2O (400 mL) and H3PO4 was added until pH=3.0. The reaction was kept being stirred at 120° C. overnight. After being cooled, NaCl (300 g) was added, and the reaction was extracted with EtOAc, dried over MgSO4, and evaporated to give the crude 4-Hydroxy-2-(3-methoxybenzyl)cyclopent-2-enone and 4-Hydroxy-5-(3-methoxybenzyl)cyclopent-2-enone as black oil: 19 g (crude yield: 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08350090B1 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-e20b4eea37514eeda645fc7e517d0806 |
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| Source note | uspto-grants-2013_01 |
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