HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1803633Generated: October 31, 2026
Phosphoric Acid → 4-Hydroxy-2-(3-benzyloxybenzyl)cyclopent-2-enone
https://huagongshe.com/reaction/1803633
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Monobasic potassium phosphate | HCID 516951 | — |
| Reactant | HCID 71170040 | HCID 71170040 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Hydroxy-2-(3-benzyloxybenzyl)cyclopent-2-enone | HCID 71170034 | — |
| Product | 4-Hydroxy-5-(3-benzyloxybenzyl)cyclopent-2-enone | HCID 71170037 | — |
Reaction Steps
1-(Furan-2-yl)-2-(3-benzyloxyphenyl)ethan-1-ol (3.97 kg, 13.49 mol) and KH2PO4 (120 g, 0.88 mol) was added to H2O (120 L) and H3PO4 was added until pH=3. The reaction was kept being stirred at 120° C. for 5 hours. After being cooled, NaCl (25 kg) was added, and the reaction was extracted with EtOAc, dried over MgSO4, and evaporated to give the crude 4-hydroxy-2-(3-benzyloxybenzyl)cyclopent-2-enone and 4-hydroxy-5-(3-benzyloxybenzyl)cyclopent-2-enone as black oil: 3.4 kg (crude yield: 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08350090B1 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-42203a1653da4d6ca6fa4e22ac191d05 |
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| Source note | uspto-grants-2013_01 |
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