Chloroform → HCID 22321207, compound

HRID 1803799Notes

Reaction equation

HRID 1803799 reaction equation
[CH2:1]=[CH:2][CH2:3][CH:4]([OH:6])C.[Br:7][C:8]([CH3:13])([CH3:12])[C:9](Br)=[O:10].[CH:14](Cl)(Cl)Cl>>[Br:7][C:8]([CH3:13])([CH3:12])[C:9]([O:6][CH2:4][CH2:3][CH2:2][CH:1]=[CH2:14])=[O:10]

Participants

4

Reactant 3

HCID 6212Chloroform2×HCID 122474-Penten-2-OLHCID 886852-Bromo-2-methylpropionyl bromide

Product 1

HCID 22321207HCID 22321207, compound

Conditions

Temperature
0 °C

Procedure

160 mmol (13.9 g) penten-4-ol and 50 ml chloroform were introduced into a flask and cooled to 0° C. 160 mmol (36.8 g) bromoisobutyryl bromide in 20 ml chloroform were introduced slowly with cooling and the resulting solution was stirred for 4 h at room temperature. The reaction solution was washed three times with water, dried over MgSO4 and then concentrated by evaporation. The product was distilled in a high vacuum. Boiling point at 3.3×102 mbar: 50° C. Yield: 34.79 g (148 mmol; 92.5%)

Workup

  1. temperaturewith cooling
  2. washThe reaction solution was washed three times with water
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated by evaporation
  5. distillationThe product was distilled in a high vacuum
  6. custom50° C

Sources & evidence

ORD record
ord-a06f2be6c8ed4bc397a1f1a5c6d2aac7
Source dataset
uspto-grants-2013_01
Patent number
US08354028B2

Reaction notes

Loading…