HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-[(3,5-Difluorobenzyl)oxy]-2-nitrobenzonitrile → 2-Amino-5-[(3,5-difluorobenzyl)oxy]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-[(3,5-Difluorobenzyl)oxy]-2-nitrobenzonitrile | HCID 66996234 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Amino-5-[(3,5-difluorobenzyl)oxy]benzonitrile | HCID 66997122 | 86% |
Reaction Steps
A mixture of 5-[(3,5-difluorobenzyl)oxy]-2-nitrobenzonitrile (1 g, 3.44 mmol) and palladium 5% on carbon (150 mg) in 1,4-dioxane (20 mL) was treated under hydrogen atmosphere (40 psi) at room temperature. After 4 hours, the mixture was filtered on a celite pad and evaporated to dryness affording 770 mg (yield 86%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354399B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-b179b42a8ac040858e07b67ccea978d0 |
| Source note | uspto-grants-2013_01 |