反应详情

5-Fluoro-2-nitro-benzonitrile (5 g, 30.1 mmol) in dry DMF (60 mL) was treated first with cesium carbonate (11.7 g, 36.12 mmol) followed by 3,5-difluoro-phenol. The reaction was stirred at room temperature for 1 hour and then poured into iced water (600 mL). After stirring for 2 hours, a pale yellow solid was filtered with suction, washed with water furnishing, after drying at 50° C. under vacuum, 7.73 g of title compound in 93% yield.

1. stirringAfter stirring for 2 hours
2. filtrationa pale yellow solid was filtered with suction
3. washwashed with water furnishing
4. dry with materialafter drying at 50° C. under vacuum, 7.73 g of title compound in 93% yield