HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 66997240, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 58513763 | HCID 58513763 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 66997240 | HCID 66997240 | — |
Reaction Steps
To a solution of tert-butyl 4-(4-{[5-(benzyloxy)-1H-indazol-3-yl]carbamoyl}-1H-pyrazol-1-yl)piperidine-1-carboxylate (100 mg, 0.19 mmol) in dioxane (4 mL), 4M HCl in dioxane (0.72 ml, 2.88 mmol) was added. The mixture was stirred at room temperature for 18 hours. The solvent was removed under reduced pressure and the crude was diluted with Et2O and decanted, to give after filtration, the final compound as hydrochloride salt (80 mg, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354399B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-0d919ad3a4e04fd0a4828b8c73f69d41 |
| Source note | uspto-grants-2013_01 |