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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1803855Generated: November 2, 2026

Hydrochloric Acid → HCID 66997240, compound

https://huagongshe.com/reaction/1803855

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 58513763HCID 58513763—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 66997240HCID 66997240—

Reaction Steps

To a solution of tert-butyl 4-(4-{[5-(benzyloxy)-1H-indazol-3-yl]carbamoyl}-1H-pyrazol-1-yl)piperidine-1-carboxylate (100 mg, 0.19 mmol) in dioxane (4 mL), 4M HCl in dioxane (0.72 ml, 2.88 mmol) was added. The mixture was stirred at room temperature for 18 hours. The solvent was removed under reduced pressure and the crude was diluted with Et2O and decanted, to give after filtration, the final compound as hydrochloride salt (80 mg, 93%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354399B2
Source datasetuspto-grants-2013_01
ORD IDord-0d919ad3a4e04fd0a4828b8c73f69d41
Source noteuspto-grants-2013_01