Hydrochloric Acid → HCID 66997240, compound

HRID 1803855Notes

Reaction equation

HRID 1803855 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][N:13]=[C:12]2[NH:18][C:19]([C:21]1[CH:22]=[N:23][N:24]([CH:26]2[CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28][CH2:27]2)[CH:25]=1)=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:39]>O1CCOCC1>[ClH:39].[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][N:13]=[C:12]2[NH:18][C:19]([C:21]1[CH:22]=[N:23][N:24]([CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH:25]=1)=[O:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58513763HCID 58513763, compound

Product 1

HCID 66997240HCID 66997240, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl 4-(4-{[5-(benzyloxy)-1H-indazol-3-yl]carbamoyl}-1H-pyrazol-1-yl)piperidine-1-carboxylate (100 mg, 0.19 mmol) in dioxane (4 mL), 4M HCl in dioxane (0.72 ml, 2.88 mmol) was added. The mixture was stirred at room temperature for 18 hours. The solvent was removed under reduced pressure and the crude was diluted with Et2O and decanted, to give after filtration, the final compound as hydrochloride salt (80 mg, 93%).

Workup

  1. customThe solvent was removed under reduced pressure
  2. additionthe crude was diluted with Et2O
  3. customdecanted
  4. customto give
  5. filtrationafter filtration

Sources & evidence

ORD record
ord-0d919ad3a4e04fd0a4828b8c73f69d41
Source dataset
uspto-grants-2013_01
Patent number
US08354399B2

Reaction notes

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