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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1803933Generated: October 26, 2026

1-(2,4-Xylyl)piperazine → (4-Bromo-3-chlorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

https://huagongshe.com/reaction/1803933

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2,4-Xylyl)piperazineHCID 70544—
Reactant4-Bromo-3-chlorobenzoic acidHCID 12594302—
Product(4-Bromo-3-chlorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanoneHCID 58484864100.7%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 1 and using 4-bromo-3-chlorobenzoic acid (2.4 g) and 1-(2,4-dimethylphenyl)piperazine (1.9 g), the title compound (4.1 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-8a8857b968704d5783d02d9c8c790f32
Source noteuspto-grants-2013_01