2-Oxazolidinone → 3-{5-[4-(4-Chlorobenzoyl)piperidine-1-carbonyl]pyridin-2-yl}oxazolidin-2-one

HRID 1803968Notes

Reaction equation

HRID 1803968 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][CH:13]([C:16](=[O:24])[C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[O:25]1[CH2:29][CH2:28][NH:27][C:26]1=[O:30]>>[Cl:23][C:20]1[CH:21]=[CH:22][C:17]([C:16]([CH:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:4]=[CH:3][C:2]([N:27]4[CH2:28][CH2:29][O:25][C:26]4=[O:30])=[N:7][CH:6]=3)=[O:9])[CH2:11][CH2:12]2)=[O:24])=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 739492-OxazolidinoneHCID 58484839(6-Bromopyridin-3-yl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone

Product 1

HCID 547551163-{5-[4-(4-Chlorobenzoyl)piperidine-1-carbonyl]pyridin-2-yl}oxazolidin-2-oneYield 12.8%

Procedure

By reaction and treatment in the same manner as in Preparation Example 31 and using (6-bromopyridin-3-yl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone (2 g) described in Preparation Example 23 and oxazolidin-2-one (435 mg), the title compound (260 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 31

Sources & evidence

ORD record
ord-ab0d7fa49e114369832fa87a904d9930
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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