HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4R)-4-ethyl-1,3-oxazolidin-2-one → (R)-3-{5-[4-(4-chlorobenzoyl)piperidine-1-carbonyl]pyridin-2-yl}-4-ethyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4R)-4-ethyl-1,3-oxazolidin-2-one | HCID 641503 | — |
| Reactant | (6-Bromopyridin-3-yl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone | HCID 58484839 | — |
| Product | (R)-3-{5-[4-(4-chlorobenzoyl)piperidine-1-carbonyl]pyridin-2-yl}-4-ethyloxazolidin-2-one | HCID 54755118 | 61.7% |
Reaction Steps
By reaction and treatment in the same manner as in Preparation Example 31 and using (6-bromopyridin-3-yl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone (2 g) described in Preparation Example 23 and (R)-4-ethyloxazolidin-2-one (300 mg) described in Preparation Example 26, the title compound (710 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-efb87ac04d4b4ee1b8144dbfbafc1b6e |
| Source note | uspto-grants-2013_01 |