5-Bromopyridine-2-carboxylic acid → (5-Bromopyridin-2-yl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone

HRID 1803971Notes

Reaction equation

HRID 1803971 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.Cl.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([CH:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[O:20])=[CH:15][CH:14]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:24]2[CH2:25][CH2:26][CH:21]([C:19](=[O:20])[C:16]3[CH:15]=[CH:14][C:13]([Cl:12])=[CH:18][CH:17]=3)[CH2:22][CH2:23]2)=[O:10])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 6085445-Bromopyridine-2-carboxylic acidHCID 27771144-(4-Chlorobenzoyl)piperidine hydrochloride

Product 1

HCID 58484577(5-Bromopyridin-2-yl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanoneYield 99.1%

Procedure

By reaction and treatment in the same manner as in Preparation Example 27 and using 5-bromopyridine-2-carboxylic acid (1.2 g) and (4-chlorophenyl)piperidin-4-ylmethanone hydrochloride (1.6 g), the title compound (2.4 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 27

Sources & evidence

ORD record
ord-332627213511430e9f2eaad83e348404
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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