反应详情

A mixture of 0.81 mmol of butyryl chloride and 0.673 mmol of AlCl3 in 2 ml of anhydrous dichloromethane is added in small portions to 0.135 mmol of the product of Example 2 in 2 ml of dichloromethane at 0° C. The reaction mixture is stirred for 4 hours at ambient temperature and then poured into a 10% solution of HCl. Following conventional treatment of the organic phases, and evaporation thereof under reduced pressure, chromatography of the residue on silica gel (dichloromethane/methanol gradient) allows the expected product to be isolated.

1. customtreatment of the organic phases, and evaporation
2. customto be isolated