Hydrogen chloride-ethyl acetate → 1-(3-Ethyl-5-methylpyridin-2-yl)piperazine hydrochloride

HRID 1804000Notes

Reaction equation

HRID 1804000 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([Cl:20])=[CH:18][C:17]([CH3:21])=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.[C:23](OCC)(=O)[CH3:24]>>[ClH:20].[CH2:23]([C:19]1[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[N:15][CH:16]=[C:17]([CH3:21])[CH:18]=1)[CH3:24]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 673809194-(3-Chloro-5-methylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 673808571-(3-Ethyl-5-methylpyridin-2-yl)piperazine hydrochloride

Procedure

By reaction and treatment in the same manner as in Example 53 and using 4-(3-chloro-5-methylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (9 g), which is the intermediate described in Preparation Example 48, a compound was obtained, which was treated with 4N hydrogen chloride/ethyl acetate (2 mL) to give the title compound (1.1 g).

Workup

  1. customBy reaction and treatment in the same manner as in Example 53
  2. customdescribed in Preparation Example 48
  3. customa compound was obtained

Sources & evidence

ORD record
ord-5267de9e4ea840cf9ef849d61528ebb0
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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