Hydrogen chloride-ethyl acetate → 1-(3-Ethyl-5-methylpyridin-2-yl)piperazine hydrochloride

Participants

Reaction Steps

By reaction and treatment in the same manner as in Example 53 and using 4-(3-chloro-5-methylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (9 g), which is the intermediate described in Preparation Example 48, a compound was obtained, which was treated with 4N hydrogen chloride/ethyl acetate (2 mL) to give the title compound (1.1 g).

Provenance & Evidence