Ethyl 4-iodobenzoate → (R)-4-(4-ethyl-2-oxooxazolidin-3-yl)benzoic acid

HRID 1804025Notes

Reaction equation

HRID 1804025 reaction equation
I[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[CH:4][CH:3]=1.[CH2:13]([C@@H:15]1[CH2:19][O:18][C:17](=[O:20])[NH:16]1)[CH3:14]>>[CH2:13]([C@@H:15]1[CH2:19][O:18][C:17](=[O:20])[N:16]1[C:2]1[CH:3]=[CH:4][C:5]([C:6]([OH:8])=[O:7])=[CH:11][CH:12]=1)[CH3:14]

Participants

3

Reactant 2

HCID 142891Ethyl 4-iodobenzoateHCID 641503(4R)-4-ethyl-1,3-oxazolidin-2-one

Product 1

HCID 58484770(R)-4-(4-ethyl-2-oxooxazolidin-3-yl)benzoic acid

Procedure

By reaction and treatment in the same manner as in Preparation Example 18 and using ethyl 4-iodobenzoate (1.4 mL) and (R)-4-ethyloxazolidin-2-one (979 mg) described in Preparation Example 26, the title compound (2.6 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 18
  3. customdescribed in Preparation Example 26

Sources & evidence

ORD record
ord-d4b4bf98a74b438da2f829860979d935
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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