Ethyl 4-iodobenzoate → (R)-4-(2-oxo-4-propyloxazolidin-3-yl)benzoic acid

HRID 1804026Notes

Reaction equation

HRID 1804026 reaction equation
I[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[CH:4][CH:3]=1.[CH2:13]([C@@H:16]1[CH2:20][O:19][C:18](=[O:21])[NH:17]1)[CH2:14][CH3:15]>>[CH2:13]([C@@H:16]1[CH2:20][O:19][C:18](=[O:21])[N:17]1[C:2]1[CH:3]=[CH:4][C:5]([C:6]([OH:8])=[O:7])=[CH:11][CH:12]=1)[CH2:14][CH3:15]

Participants

3

Reactant 2

HCID 142891Ethyl 4-iodobenzoateHCID 2734859(4R)-4-Propyl-2-oxazolidinone

Product 1

HCID 58484846(R)-4-(2-oxo-4-propyloxazolidin-3-yl)benzoic acid

Procedure

By reaction and treatment in the same manner as in Preparation Example 18 and using ethyl 4-iodobenzoate (3.2 mL) and (R)-4-propyloxazolidin-2-one (2.5 g) described in Preparation Example 29, the title compound (5.7 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 18
  3. customdescribed in Preparation Example 29

Sources & evidence

ORD record
ord-846ed9f5f6aa4559b318bb374851e081
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

Loading…