4-Bromo-2-methanesulfonylbenzoic acid → (4-Bromo-2-methanesulfonylphenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804030Notes

Reaction equation

HRID 1804030 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:3]=1.Cl.[CH3:16][C:17]1[C:18]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[N:19][C:20]([CH3:24])=[C:21]([CH3:23])[CH:22]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:28]2[CH2:29][CH2:30][N:25]([C:18]3[C:17]([CH3:16])=[CH:22][C:21]([CH3:23])=[C:20]([CH3:24])[N:19]=3)[CH2:26][CH2:27]2)=[O:8])=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:3]=1

Participants

3

Reactant 2

HCID 27610574-Bromo-2-methanesulfonylbenzoic acidHCID 673810521-(3,5,6-Trimethylpyridin-2-yl)piperazine hydrochloride

Product 1

HCID 58484785(4-Bromo-2-methanesulfonylphenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanoneYield 51.8%

Procedure

By reaction and treatment in the same manner as in Preparation Example 27 and using 4-bromo-2-methanesulfonylbenzoic acid (3.5 g) and 1-(3,5,6-trimethylpyridin-2-yl)piperazine hydrochloride (3 g) described in Preparation Example 52, the title compound (3 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 27
  3. customdescribed in Preparation Example 52

Sources & evidence

ORD record
ord-9fe689d9b5b04f5c97c15848f26a9357
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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