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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804032Generated: October 31, 2026

4-Bromo-2-methanesulfonylbenzoic acid → (4-Bromo-2-methanesulfonylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

https://huagongshe.com/reaction/1804032

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Bromo-2-methanesulfonylbenzoic acidHCID 2761057—
Reactant1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochlorideHCID 67381091—
Product(4-Bromo-2-methanesulfonylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneHCID 5848482194.1%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 27 and using 4-bromo-2-methanesulfonylbenzoic acid (558 mg) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride (508 mg) described in Preparation Example 49, the title compound (0.9 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-f24850e1636d4eeba937d96f7a725e15
Source noteuspto-grants-2013_01