4-Bromo-2-methanesulfonylbenzoic acid → (4-Bromo-2-methanesulfonylphenyl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804036Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804036
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:3]=1.[CH:15]1([C:18]2[C:19]([N:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)=[N:20][CH:21]=[C:22]([CH:24]3[CH2:26][CH2:25]3)[CH:23]=2)[CH2:17][CH2:16]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:30]2[CH2:31][CH2:32][N:27]([C:19]3[C:18]([CH:15]4[CH2:16][CH2:17]4)=[CH:23][C:22]([CH:24]4[CH2:26][CH2:25]4)=[CH:21][N:20]=3)[CH2:28][CH2:29]2)=[O:8])=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:3]=1

Komponenten

3

Edukt 2

HCID 27610574-Bromo-2-methanesulfonylbenzoic acidHCID 584847011-(3,5-Dicyclopropylpyridin-2-yl)piperazine

Produkt 1

HCID 58484601(4-Bromo-2-methanesulfonylphenyl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanoneAusbeute 73 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Preparation Example 38 and using 4-bromo-2-methanesulfonylbenzoic acid (2.29 g) and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine (2 g) described in Preparation Example 62, the title compound (3.02 g) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 38
  3. customdescribed in Preparation Example 62

Quellen und Nachweise

ORD-Eintrag
ord-51ee6f98b8294464935b355b27a0c143
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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