4-Bromo-2-fluorobenzoyl chloride → (4-Bromo-2-fluorophenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804049Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804049
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[C:4]([F:11])[CH:3]=1.Cl.[CH2:13]([C:15]1[CH:16]=[C:17]([CH3:27])[C:18]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[N:19][CH:20]=1)[CH3:14]>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:24]2[CH2:25][CH2:26][N:21]([C:18]3[C:17]([CH3:27])=[CH:16][C:15]([CH2:13][CH3:14])=[CH:20][N:19]=3)[CH2:22][CH2:23]2)=[O:7])=[C:4]([F:11])[CH:3]=1

Komponenten

3

Edukt 2

HCID 27340264-Bromo-2-fluorobenzoyl chlorideHCID 673809241-(5-Ethyl-3-methylpyridin-2-yl)piperazine hydrochloride

Produkt 1

HCID 58484537(4-Bromo-2-fluorophenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneAusbeute 99,2 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Preparation Example 8 and using 4-bromo-2-fluorobenzoyl chloride (2.4 g) and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine hydrochloride (2.4 g) described in Preparation Example 99, the title compound (4 g) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 8
  3. customdescribed in Preparation Example 99

Quellen und Nachweise

ORD-Eintrag
ord-2bc27c99f4fa49688a7136d9952bf6d8
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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