1-(5-Bromo-3-methylpyridin-2-yl)piperazine → HCID 58484740, compound

HRID 1804061Notes

Reaction equation

HRID 1804061 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[Br:12][C:13]1[CH:14]=[C:15]([CH3:25])[C:16]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:17][CH:18]=1>>[Br:12][C:13]1[CH:14]=[C:15]([CH3:25])[C:16]([N:19]2[CH2:20][CH2:21][N:22]([C:6]([C:5]3[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=3[CH3:11])=[O:8])[CH2:23][CH2:24]2)=[N:17][CH:18]=1

Participants

3

Reactant 2

HCID 467392701-(5-Bromo-3-methylpyridin-2-yl)piperazineHCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acid

Product 1

HCID 58484740HCID 58484740, compoundYield 43.4%

Procedure

By reaction and treatment in the same manner as in Preparation Example 69 and using 6-fluoro-4-methylnicotinic acid (931 mg) and 1-(5-bromo-3-methylpyridin-2-yl)piperazine (1.5 g), the title compound (1 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 69

Sources & evidence

ORD record
ord-125e8a21052c4df7ad44c96b6a00f346
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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