2-Oxazolidinone → Methyl 2-(1,1-dioxoisothiazolidin-2-yl)-4-(2-oxooxazolidin-3-yl)benzoate

HRID 1804064Notes

Reaction equation

HRID 1804064 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([N:12]2[CH2:16][CH2:15][CH2:14][S:13]2(=[O:18])=[O:17])[CH:3]=1.[O:19]1[CH2:23][CH2:22][NH:21][C:20]1=[O:24]>>[O:17]=[S:13]1(=[O:18])[CH2:14][CH2:15][CH2:16][N:12]1[C:4]1[CH:3]=[C:2]([N:21]2[CH2:22][CH2:23][O:19][C:20]2=[O:24])[CH:11]=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7]

Participants

3

Reactant 2

HCID 739492-OxazolidinoneHCID 58484624Methyl 4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoate

Product 1

HCID 58484747Methyl 2-(1,1-dioxoisothiazolidin-2-yl)-4-(2-oxooxazolidin-3-yl)benzoateYield 37.7%

Procedure

By reaction and treatment in the same manner as in Preparation Example 12 and using methyl 4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoate (2 g) described in Preparation Example 116 and oxazolidin-2-one (515 mg), the title compound (758 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 12

Sources & evidence

ORD record
ord-8f96173681e04c26ad168ce511e91c94
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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