HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-(methylsulfonamido)benzoic acid → N-{5-bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-(methylsulfonamido)benzoic acid | HCID 22621082 | — |
| Reactant | 1-(3,5-Dimethylpyridin-2-yl)piperazine | HCID 58484496 | — |
| Product | N-{5-bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}methanesulfonamide | HCID 58484868 | 21% |
Reaction Steps
By reaction and treatment in the same manner as in Preparation Example 60 and using 4-bromo-2-methanesulfonylaminobenzoic acid (0.964 g) described in Preparation Example 122 and 1-(3,5-dimethylpyridin-2-yl)piperazine (0.629 g) described in Preparation Example 47, the title compound (0.321 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-01858155c80c4982a9000299499e5f34 |
| Source note | uspto-grants-2013_01 |