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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804071Generated: October 31, 2026

4-Bromo-2-(methylsulfonamido)benzoic acid → N-{5-bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}methanesulfonamide

https://huagongshe.com/reaction/1804071

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Bromo-2-(methylsulfonamido)benzoic acidHCID 22621082—
Reactant1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 58484718—
ProductN-{5-bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}methanesulfonamideHCID 5848482679.9%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 60 and using 4-bromo-2-methanesulfonylaminobenzoic acid (1 g) described in Preparation Example 122 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (0.739 g) described in Preparation Example 96, the title compound (1.34 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-af639e5b078c45e0b3c8189853346b88
Source noteuspto-grants-2013_01