1,4-Butanesultam → [4-Chloro-2-(1,1-dioxo-1,2-thiazinan-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804075Notes

Reaction equation

HRID 1804075 reaction equation
Br[C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][N:18]=2)[CH2:13][CH2:12]1)=[O:10].[CH2:25]1[CH2:32][NH:31][S:28](=[O:30])(=[O:29])[CH2:27][CH2:26]1>>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][N:18]=3)[CH2:13][CH2:12]2)=[O:10])=[C:2]([N:31]2[CH2:32][CH2:25][CH2:26][CH2:27][S:28]2(=[O:30])=[O:29])[CH:7]=1

Participants

3

Reactant 2

HCID 3035081,4-ButanesultamHCID 58484730(2-Bromo-4-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 58484702[4-Chloro-2-(1,1-dioxo-1,2-thiazinan-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneYield 28,857.199%

Procedure

By reaction and treatment in the same manner as in Preparation Example 12 and using (2-bromo-4-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (1.19 mg) described in Preparation Example 119 and 1,4-butanesultam (0.394 g), the title compound (0.389 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 12

Sources & evidence

ORD record
ord-c900c026ff6649178d9316490e198914
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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