1,4-Butanesultam → [4-Chloro-2-(1,1-dioxo-1,2-thiazinan-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Participants

Role	Name	HCID	Charge
Reactant	1,4-Butanesultam	HCID 303508	—
Reactant	(2-Bromo-4-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone	HCID 58484730	—
Product	[4-Chloro-2-(1,1-dioxo-1,2-thiazinan-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone	HCID 58484702	28,857.199%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 12 and using (2-bromo-4-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (1.19 mg) described in Preparation Example 119 and 1,4-butanesultam (0.394 g), the title compound (0.389 g) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08354401B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-c900c026ff6649178d9316490e198914
Source note	uspto-grants-2013_01