6-Bromonicotinic acid → 6-[4-(6-Bromopyridine-3-carbonyl)piperazin-1-yl]-5-methylnicotinonitrile

HRID 1804078Notes

Reaction equation

HRID 1804078 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:11][C:12]1[C:13]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:14][CH:15]=[C:16]([CH:19]=1)[C:17]#[N:18]>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:13]3[C:12]([CH3:11])=[CH:19][C:16]([C:17]#[N:18])=[CH:15][N:14]=3)[CH2:21][CH2:22]2)=[O:8])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 2389326-Bromonicotinic acidHCID 673812745-Methyl-6-(piperazin-1-yl)nicotinonitrile

Product 1

HCID 584845186-[4-(6-Bromopyridine-3-carbonyl)piperazin-1-yl]-5-methylnicotinonitrileYield 74.2%

Procedure

By reaction and treatment in the same manner as in Preparation Example 60 and using 6-bromonicotinic acid (500 mg) and 5-methyl-6-piperazin-1-ylnicotinonitrile (501 mg), the title compound (709 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 60

Sources & evidence

ORD record
ord-8a79e71abd1344f681baea033a33b352
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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