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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804078Generated: October 26, 2026

6-Bromonicotinic acid → 6-[4-(6-Bromopyridine-3-carbonyl)piperazin-1-yl]-5-methylnicotinonitrile

https://huagongshe.com/reaction/1804078

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Bromonicotinic acidHCID 238932—
Reactant5-Methyl-6-(piperazin-1-yl)nicotinonitrileHCID 67381274—
Product6-[4-(6-Bromopyridine-3-carbonyl)piperazin-1-yl]-5-methylnicotinonitrileHCID 5848451874.2%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 60 and using 6-bromonicotinic acid (500 mg) and 5-methyl-6-piperazin-1-ylnicotinonitrile (501 mg), the title compound (709 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-8a79e71abd1344f681baea033a33b352
Source noteuspto-grants-2013_01