HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-methylbenzoic acid → 6-[4-(4-Bromo-2-methylbenzoyl)piperazin-1-yl]-5-methylnicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-methylbenzoic acid | HCID 99570 | — |
| Reactant | 5-Methyl-6-(piperazin-1-yl)nicotinonitrile | HCID 67381274 | — |
| Product | 6-[4-(4-Bromo-2-methylbenzoyl)piperazin-1-yl]-5-methylnicotinonitrile | HCID 58484676 | 106.8% |
Reaction Steps
By reaction and treatment in the same manner as in Preparation Example 60 and using 4-bromo-2-methylbenzoic acid (215 mg) and 5-methyl-6-piperazin-1-ylnicotinonitrile (202 mg), the title compound (426 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-7fcc89abe0994ab0a63bf607d6f99a94 |
| Source note | uspto-grants-2013_01 |