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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804083Generated: October 27, 2026

6-Fluoro-4-methylpyridine-3-carboxylic acid → [4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone

https://huagongshe.com/reaction/1804083

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Fluoro-4-methylpyridine-3-carboxylic acidHCID 46739274—
Reactant1-(5-Ethyl-3-methylpyridin-2-yl)piperazineHCID 58484578—
Product[4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanoneHCID 5848460259.1%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 60 and using 6-fluoro-4-methylnicotinic acid (500 mg) and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (649 mg) described in Preparation Example 53, the title compound (640 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-3ec5b62dffda4079a5d14da98e3546ef
Source noteuspto-grants-2013_01