2-Oxazolidinone → 6-(2-Oxooxazolidin-3-yl)nicotinic acid methyl ester

HRID 1804084Notes

Reaction equation

HRID 1804084 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[O:12]1[CH2:16][CH2:15][NH:14][C:13]1=[O:17]>>[CH3:9][O:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([N:14]2[CH2:15][CH2:16][O:12][C:13]2=[O:17])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 739492-OxazolidinoneHCID 13349623Methyl 6-bromopyridine-3-carboxylate

Product 1

HCID 584844956-(2-Oxooxazolidin-3-yl)nicotinic acid methyl esterYield 78.8%

Procedure

By reaction and treatment in the same manner as in Preparation Example 12 and using methyl 6-bromonicotinate (1 g) and oxazolidin-2-one (474 mg), the title compound (810 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 12

Sources & evidence

ORD record
ord-4328fde310a84dcd8457157246093512
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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