6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804095Notes

Reaction equation

HRID 1804095 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH:11]1([C:14]2[C:15]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)=[N:16][CH:17]=[C:18]([CH3:20])[CH:19]=2)[CH2:13][CH2:12]1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:24]2[CH2:25][CH2:26][N:21]([C:15]3[C:14]([CH:11]4[CH2:13][CH2:12]4)=[CH:19][C:18]([CH3:20])=[CH:17][N:16]=3)[CH2:22][CH2:23]2)=[O:8])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 2389326-Bromonicotinic acidHCID 584846211-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazine

Product 1

HCID 86658776(6-Bromopyridin-3-yl)[4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl]methanoneYield 46.3%

Procedure

By reaction and treatment in the same manner as in Preparation Example 27 and using 6-bromonicotinic acid (185 mg) and 1-(3-cyclopropyl-5-methylpyridin-2-yl)piperazine (210 mg), the title compound (170 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 27

Sources & evidence

ORD record
ord-5ff30b05e73b4053acf4e9cabdca86f1
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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