Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804095Generated: October 31, 2026

6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl]methanone

https://huagongshe.com/reaction/1804095

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Bromonicotinic acidHCID 238932—
Reactant1-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazineHCID 58484621—
Product(6-Bromopyridin-3-yl)[4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl]methanoneHCID 8665877646.3%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 27 and using 6-bromonicotinic acid (185 mg) and 1-(3-cyclopropyl-5-methylpyridin-2-yl)piperazine (210 mg), the title compound (170 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-5ff30b05e73b4053acf4e9cabdca86f1
Source noteuspto-grants-2013_01