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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804096Generated: November 1, 2026

6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

https://huagongshe.com/reaction/1804096

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Bromonicotinic acidHCID 238932—
Reactant1-(5-Ethyl-3-methylpyridin-2-yl)piperazineHCID 58484578—
Product(6-Bromopyridin-3-yl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneHCID 5848465255%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 27 and using 6-bromonicotinic acid (500 mg) and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (586 mg) described in Preparation Example 53, the title compound (530 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-29e6667415b34ba8be974f50742ce8a3
Source noteuspto-grants-2013_01